Innovative Drug Delivery & Medical Devices from Gram Medical
Today, many therapies rely on injections because oral delivery often suffers from poor absorption and limited payload compatibility. Gram Medical’s approach is a fully customizable single and multi-chamber oral capsule delivery platform incorporating proprietary gastrointestinal alignment that increases bioavailability and enables predictable short or extended release.
Biopsy procedures can rupture a tumor and disperse cells, raising dissemination risk and missing the opportunity for immediate site directed therapy. Gram Medical’s approach is a biopsy driven local delivery step: a bioabsorbable, slow dissolving insert can be placed at the site to reduce dissemination risk, concentrate treatment locally, and enable contactless, extended therapy. The insert can be configured with heat-responsive elements, time-release drugs, and/or light-emitting materials depending on program needs.
Clear, marketable benefits for partners, OEMs, and investors—rooted in protected, GI-aware delivery and a manufacturable architecture.
Conventional tablets disintegrate in bulk gastric fluid, exposing drug to acid and enzymes with limited residence at absorptive mucosa — resulting in low and variable bioavailability.
A protected, GI-aware capsule presents drug directly to absorptive mucosa, shields sensitive payloads from acid and enzymes, and uses permeability enhancers plus configurable release elements to raise uptake and smooth exposure targeting higher, more reliable bioavailability with reduced peaks, troughs, and total dose.
Current biopsy procedures can rupture a tumor, potentially seeding nearby tissues and/or leaking unwanted cells into the bloodstream where they could travel to new sites in the patient’s body.
Gram Medical’s approach adds a localized therapy step to the biopsy workflow using a bioabsorbable, slow-dissolving material placed at the target.
